Our lab develops simulations of chemical reactions and biological signaling pathways that shape cardiac and immune function at the molecular through cellular scales. Our tools include computer vision and numerical algorithms, molecular simulations, and applied mathematics to bridge molecular-scale physical chemistry with chemical phenomena that emerge at much larger length scales. Among our interests, our approaches address general questions including
• Can the functions of Ca2+ handling proteins be predicted and redesigned in silico? 
• How do intracellular signaling networks respond to environmental and subcellular queues? 
• How do molecular interactions in materials govern and respond to transport phenomena at sub-micron
and longer length-scales? 

In answering these questions, we are pursuing our long term goal of understanding how biological signaling pathways are controlled at the molecular through cellular levels, how they are perturbed in disease and how
they could be safely modulated through small molecules and protein engineering.   Additional information on specific research themes may be found on our Research page. 
Our research has been supported through the National Institutes of Health, NASA and the Petroleum Research Fund. The current research areas span the following:
- computer simulations of chemical and biological systems
- systems biology modeling of cell behavior
- computational analysis of imaging data

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